Dogs Have More Cannabinoid Receptors: What It Means for Their Health | Hemp Well
Dogs are unique in how their bodies respond to cannabinoids. Unlike humans, dogs have more cannabinoid receptors throughout their brain and nervous system. This means they are highly sensitive to tetrahydrocannabinol (THC), the psychoactive compound in cannabis, but they may also respond very well to cannabidiol (CBD), which is non-psychoactive and beneficial.
Dogs and THC: Why It’s Dangerous
Because of the abundance of receptors, if your dog eats something like a marijuana brownie, they could remain “high” for up to two full days. Symptoms can include lethargy, imbalance, drooling, tremors, or vomiting. THC toxicity in dogs can be serious and requires veterinary care.
Dogs and CBD: Why Less Is More
On the flip side, CBD interacts with those same receptors in a positive way—helping with anxiety, pain, inflammation, and overall wellness. For dogs, a little CBD goes a long way. That’s why Hemp Well products are carefully formulated to deliver precise, safe amounts of CBD without THC.
The Endocannabinoid System in Dogs
The endocannabinoid system (ECS) is a network of receptors (CB1 and CB2) responsible for regulating mood, sleep, appetite, pain, and immune response. Since dogs have more of these receptors than most mammals, they feel stronger effects from cannabinoids—both good and bad.

Safe Hemp-Derived Support for Dogs
At Hemp Well, we’ve been sourcing organic hemp responsibly since 2012. Our products are crafted to support your pet naturally and safely:
- Calm CBD Dog Chews – for relaxation and stress relief.
- Relief CBD Dog Chews – for joint comfort and inflammation support.
- CBD Oils – precise dosing with droppers for everyday wellness.
Key Takeaway
Dogs’ abundance of cannabinoid receptors makes them uniquely sensitive to cannabis compounds. While THC can be dangerous, CBD provides safe, natural support for stress, discomfort, and inflammation when used correctly. Always choose trusted, THC-free products made specifically for pets.
We help pet parents like you by delivering the best products in the marketplace and information to help your dog thrive. Learn more in our Dog Wellness Collection.