Top 100 Animal Rescues in the United States

Across the country, thousands of dedicated animal rescue organizations work tirelessly to save, rehabilitate, and rehome pets and wildlife. These groups are on the frontlines of animal welfare, giving countless animals a second chance at life. Today we celebrate 100 of the most impactful rescues in the U.S., highlighting their missions and the ways you can help.

Note: This list is not ranked — each organization plays a critical role in improving animal lives, and there are many more unsung heroes beyond these organizations.

10 Inspiring Animal Rescues Leading the Way

1. Best Friends Animal Society

bestfriends.org
Location: Kanab, Utah
Mission: End the killing of dogs and cats in America’s shelters by 2025 through adoption programs, spay/neuter initiatives, and advocacy.

2. ASPCA (American Society for the Prevention of Cruelty to Animals)

aspca.org
Location: New York, New York
Mission: Prevent cruelty to animals through rescue, legislation, and education nationwide.

3. The Humane Society of the United States

humanesociety.org
Location: Washington, D.C.
Mission: Promote the protection of all animals, from pets to wildlife, through advocacy and direct care.

4. American Humane

americanhumane.org
Location: Washington, D.C.
Mission: Ensure the welfare of children and animals, famous for their “No Animals Were Harmed®” film certification.

5. Rescue Dogs Rock NYC

rescuedogsrocknyc.org
Location: New York, New York
Mission: Save dogs from high-kill shelters, provide urgent medical care, and find forever homes.

6. Hope for Paws

hopeforpaws.org
Location: Los Angeles, California
Mission: Rescue homeless animals from extreme situations and share rescue stories to inspire others.

7. The Gentle Barn

gentlebarn.org
Location: Santa Clarita, California
Mission: Rescue and rehabilitate abused farm animals while providing programs for at-risk youth.

8. Big Cat Rescue

bigcatrescue.org
Location: Tampa, Florida
Mission: End the abuse of big cats, rescue those in need, and provide lifelong care and advocacy for captive wild cats.

9. Animal Rescue League of Boston

arlboston.org
Location: Boston, Massachusetts
Mission: Rescue, rehabilitate, and rehome companion animals while protecting them from neglect.

10. Wildlife SOS

wildlifesos.org
Location: Washington, D.C. & India
Mission: Protect and conserve India’s wildlife, including elephants, bears, and leopards, through rescue operations and habitat protection.

Why Supporting Animal Rescues Matters

Each of these organizations relies on donations, volunteers, and advocates to continue their lifesaving work. Whether it’s adopting a dog, fostering kittens, donating supplies, or sponsoring a sanctuary animal, every act of kindness helps create a safer world for animals.

Looking for a local rescue to support? Check out regional rescues near you and consider donating or volunteering — your contribution could save a life.