Dogs and Cannabinoids: How Cannabinoid Receptors in Dogs Could Promote Their Health

Dogs are unique among mammals for having a high concentration of cannabinoid receptors throughout their bodies—especially in the brain and nervous system. These receptors are part of the endocannabinoid system (ECS), a complex network responsible for helping regulate mood, memory, discomfort perception, appetite, and immune response. Understanding how this system works can help pet parents better support their dog’s wellness through natural, non-medicated supplements.

What Are Cannabinoid Receptors?

Cannabinoid receptors are proteins located on cell surfaces throughout the body. When activated by naturally occurring compounds—either produced by the body (endocannabinoids) or sourced from plants like hemp (phytocannabinoids)—these receptors help maintain balance across various biological systems.
There are two primary types of cannabinoid receptors:

• CB1 receptors: Found mostly in the brain and central nervous system

• CB2 receptors: Found mainly in the immune system and peripheral organs

These receptors respond to cannabinoids like CBD (cannabidiol), which are being explored for their supportive roles in wellness.

Why Dogs May Be More Sensitive to Cannabinoids

Research shows that dogs have more cannabinoid receptors in their brains than most other species, including humans. This higher sensitivity has prompted growing interest in how the ECS in dogs responds to hemp-based compounds. Because of this sensitivity, even small amounts of cannabinoids may have noticeable effects in dogs, which is why responsible use and proper serving amounts are important.

How the Endocannabinoid System Affects Dogs

The ECS helps maintain homeostasis (internal balance) across many biological systems. When supported appropriately, it may assist with:

• Encouraging calm behavior

• Supporting joint mobility and physical comfort

• Maintaining a healthy inflammatory response

While these effects are still being researched, many pet parents report anecdotal improvements in their dogs’ well-being after incorporating hemp-derived supplements into their daily routine.

Are There Side Effects?

While most dogs tolerate hemp-derived cannabinoids well, sensitivity can vary. Some pet parents have reported mild effects such as drowsiness or digestive changes when first introducing CBD-rich products. As always, it’s best to start with a small amount and observe your dog’s response. Speak with your veterinarian before adding any new supplement to your dog’s regimen—especially if your pet is on medication or managing a chronic condition.

The Future of Canine Cannabinoid Research

As the use of hemp-based supplements grows in popularity, ongoing research aims to better understand how cannabinoids interact with the canine ECS. Scientists are exploring everything from how receptors function in different dog breeds to how plant-based compounds might support the body’s natural healing systems.

Since 2012, we’ve responsibly sourced organic hemp to help pet parents support their animals’ well-being in natural, thoughtful ways. While every dog is different, understanding the science behind the ECS and cannabinoid receptors is the first step toward informed decisions.